Manchester United replaced Manchester City as Premier League leaders with Wayne Rooney ending an 11-match run without a league goal in his side's comfortable 3-0 win over Sunderland at Old Trafford on Saturday.
Leicester City's Premier League title defence got off to a terrible start as they were beaten 2-1 at promoted Hull City, who shrugged off an injury crisis to shock the champions on the opening day of the new season on Saturday
The Professional Footballers' Association (PFA) called for a government inquiry into racism in the English game following the match, which Chelsea won 2-0.
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Giorgio Chiellini's assertion that Tottenham Hotspur 'always miss something to arrive at the end' would have chiselled deep into a nerve for fans of the north London club.
Arsenal are eighth, seven points adrift of fourth-placed Chelsea, while Norwich remain second from bottom.
Manchester United won 2-1 at Crystal Palace to consolidate fourth spot.
Following is a match by match look at the English Premier League's season-opening weekend fixtures:
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Arsenal's improbable late run at the Premier League title gained momentum with a 1-0 victory at struggling Burnley on Saturday, an eighth straight triumph that moved them within four points of leaders Chelsea.
Former Arsenal striker Ian Wright has launched a scathing attack on the club's manager Arsene Wenger, saying he could not make a case for the Frenchman to extend his reign beyond this season.
Huddersfield Town were left celebrating wildly after securing their Premier League safety on Wednesday with a dramatic and resilient 1-1 draw at Chelsea, a result that looks almost certain to condemn Swansea City to relegation.
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Manchester City stayed ahead of age-old local rivals Manchester United at the top of the Premier League on Saturday with a deserved 1-0 win away to champions Chelsea.
IMAGES from the English Premier League matches played on Wednesday
IMAGES from the English Premier League matches played on Saturday
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In April last year Leicester City were seven points adrift at the foot of the Premier League and seemingly going down.
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Manchester City returned to the Premier League summit for the first time since January with a 3-2 win at Everton on Saturday that left them six points from a second title in three seasons.
He increasingly looks like a manager unable to cope with the modern tactical realities of football. His display of a fear of failure has been appalling to watch. But Mourinho getting the sack at this juncture will hardly solve the problem, says Dhruv Munjal.
"Our first half was fantastic, we dominated the game. The second is not easy to explain," a baffled Pochettino told reporters. "No-one would expect this end to the game if you see the first half. "We need to assess and analyse the second half because it is impossible to see the team playing in such a different way."
Manchester City continued their imperious start to the season with a 2-1 win over Swansea City to reach the fourth round of the League Cup on Wednesday but it was a testing night for rivals United who eventually overcame Northampton Town 3-1.
How quickly affections can switch in soccer. Where once they would serenade coach Jose Mourinho at Stamford Bridge with an operatic flourish, now Chelsea fans have fallen headlong for another man driving them inexorably to the Premier League title.
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Former England defender Sol Campbell believes he would have been national team captain for more than 10 years if he was white, according to extracts from his new biography that is being serialised by The Sunday Times newspaper.
Samuel Eto'o's hat-trick lifted Chelsea to a 3-1 win over Manchester United on Sunday which all but ended the champions' slim hopes of defending their Premier League title.
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Images from the EPL matches played on Sunday
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Charlie Adam scored twice as Stoke City beat Manchester United 2-1 on Saturday to show the flailing Premier League champions it will take more than one big-money signing to improve their fortunes.
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Manchester City's Sergio Aguero scored a hat-trick as coach Pep Guardiola maintained his 100 per cent record at the club with a commanding 4-0 victory against Borussia Moenchengladbach in their rearranged Champions League Group C opener on Wednesday.
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Key moments in Chelsea's Premier League title-winning season.
Cristiano Ronaldo renewed his personal battle with Lionel Messi by scoring his 71st Champions League goal, putting him three behind the Argentine's newly-set record, in Real Madrid's 1-0 win at FC Basel on Wednesday.
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Tottenham Hotspur's tenacious chase of leaders Chelsea continued as they claimed a 12th consecutive Premier League home win with a 4-0 rout of Bournemouth on Saturday to cut the gap to four points.
Chelsea icon Frank Lampard scored for Manchester City to end his old club's perfect start to the Premier League season while Leicester City came from 3-1 down to beat Manchester United 5-3 on a remarkable day in the Premier League on Sunday.